Human Immune Repertoire Antibody Library

Human antibody repertoires offer vast therapeutic potential, yet most libraries derive from infected or immunized donors, limiting diversity and stability. Antibodies from naturally resilient individuals provide balanced, cross-reactive immune responses with favourable biophysical properties, enabling discovery across diverse therapeutic and diagnostic targets.

Professor Ahuva Nissim and her team at Queen Mary University of London have developed a fully human antibody library representing naturally selected immune repertoires from individuals with demonstrated immune stability.

This infection-resilience–based approach captures broad, well-behaved antibodies suited for diverse target classes.

The library is compatible with phage and yeast display platforms, enabling efficient screening and selection of high-quality, fully human antibodies