BioPharma

Synthetic Human Antibody Library for Broad Target Screening

Scientist working in a lab

Monoclonal antibody therapeutics are among the most successful drug classes, yet traditional discovery methods rely on immunisation or donor-derived B-cell repertoires. These approaches can be slow, ethically constrained, and limited in diversity.

Synthetic antibody libraries provide a renewable and fully human source of high-affinity binders for therapeutic and diagnostic applications.

Developed using structurally validated human frameworks and rationally engineered CDR diversity, the library delivers high-quality, fully human binders with improved stability and expression. It is compatible with phage, yeast, and mammalian display systems, enabling efficient screening against diverse and complex targets, including GPCRs.

Contact

Dr Maria Frolova

m.frolova@qmul.ac.uk

Inventor

Professor Ahuva Nissim

Professor in Antibody and Therapeutic Engineering

 

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